Figure 3. Neutrophils are not required for clearance of Mp from mouse lung.

(A) Greater than 90% of the CD11b⁺Gr-1^hi cells (mainly neutrophils) in mouse lung were depleted by i.v. injection with anti-Gr-1 Ab (RB6-8C5) with or without Mp infection. Data shown were collected 3 d after injection of the anti-Gr-1 Ab, and 1 d after inoculation i.n. with Mp. (B) Neutrophil depleted mice (filled bars) showed no significant difference in clearance of Mp from the lungs at all indicated times post-Mp inoculation, compared to control mice (open bars). At least three similar experiments were performed with comparable results. Data shown are means ± SEM (n = 4 or 5). P>0.05, comparing control and Gr-1 Ab injected mice at each of the time points.