Table 1. Amino-acid change coded by non-synonymous single nucleotide polymorphisms in the canine TLR4 and TLR5 gene.

	SNP	Amino-acid wild-type	Amino-acid change associated with SNP
TLR4	T23C	Valine	Alanine
	G1039A	Alanine	Threonine
	A1571T	Valine	Glutamic acid
	G1807A	Lysine	Glutamic acid
TLR5	G22A	Alanine	Threonine
	C100T	Arginine	Cystiene
	T1844C	Leucine	Serine

Amino-acid change coded by the non-synonymous single nucleotide polymorphisms (SNPs) identified in the TLR4 and TLR5 gene by mutational analysis of ten German shepherd dogs with inflammatory bowel disease (non-polar amino acids-valine, alanine and leucine, basic amino-acids-lysine and arginine, acidic amino-acid-glutamic acid and polar amino-acids-threonine, cystiene and serine).