Fig. 4.
Influence of L2-a and L2-b on metal-Aβ neurotoxicity in living cells. (A) Cell viability (%) upon incubation of CuCl2, ZnCl2, Aβ, Aβ + CuCl2, or Aβ + ZnCl2 with SK-N-BE(2)-M17 cells for 24 h, which was determined by the MTT assay. Values of cell viability depicted in the figure are relative to that of the cells only containing 1% DMSO. (B) Modulation of metal-Aβ neurotoxicity by L2-a and L2-b for 24 h ([Aβ] = 20 μM; [Cu2+ or Zn2+] = 20 μM; [compound] = 40 μM).