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. 2010 Dec 6;107(51):22060–22065. doi: 10.1073/pnas.1013147107

Fig. 2.

Fig. 2.

Model for NO-activated GC (A) and PDE5 (B). The parameters in A had the following values (15): k1 = 3 × 108 M-1 s-1, k-1 = 6 s-1, k2 = k-2 = 28 s-1, k3 = 107 M-1 s-1, k-3 = 1000 s-1, k4 = 2000 s-1, k-4 = 1.8 × 106 M-1 s-1, k5 = 7.34 × 10-4 s-1, k-5 = 4 × 108 M-1 s-1, k6 = 1 s-1, k-6 = 10-3 s-1. The PDE5 parameters are given in Table 2 and the text. Data analysis (see SI Materials and Methods) generated indistinguishable Kp and PDEmax values for the two active PDE5 species (tPDE5* and pPDE5*), and so they were designated equal.