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. 2010 Dec 22;134(1):258–277. doi: 10.1093/brain/awq341

Figure 7.

Figure 7

Cystatin B deletion in TgCRND8 elevating cathepsin activities. Results of enzymatic activity assays for cathepsin B (CatB; A), cathepsin L (CatL; B) and cathepsin D (CatD; C1) activities in brain homogenates of wild-type, CBKO, TgCRND8 and CBKO/TgCRND8 (all 6-month-old, n = 9–12 for each genotype). (C2) The cathepsin D activity shown in (C1) was recalculated against the tubulin-normalized cathepsin D values obtained from immunoblots probed with anti-cathepsin D (RU2) and anti-tubulin to yield the cathepsin D-specific activity. Values are the mean ± SEM for each group. Mean differences between genotypes were analysed by one way ANOVA followed by post hoc Bonferroni’s multiple comparison tests. *P < 0.05, **P < 0.01.