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LC-MS SRM of α-chlorodicarboxylic acid metabolites of 2-ClHA. HepG2 cells were incubated with 10 μm 2-ClHA for 24 h. Media were extracted and α-ClDCA was subjected to LC-MS using 2-ClAdA gradient 2 as mobile phase as described under “Experimental Procedures.” Molecular species were detected by indicated SRM transitions as depicted in A–C for 2-ClAdA, 2-ClTDDA, and 2-ClHDDA, respectively.
