FIGURE 6.

Mutations homologous to those identified in TRPV1 do not alter temperature and chemical sensitivity in hTRPV3. A, sample recording of whole cell current responses to consecutive application of 25–48 °C temperature ramp (10–14 °C/s) and 2-APB (300 μm) in hTRPV3 and K581E-hTRPV3. B, summary of Q₁₀- and 2-APB-induced current densities determined for wild-type and mutant hTRPV3. Each bar is the mean ± S.E. (error bars); n = 9 for wild type and 3–7 for mutants. No significant changes were detected (p = 0.344).