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. 2010 Nov 1;285(53):41567–41577. doi: 10.1074/jbc.M110.190025

FIGURE 2.

FIGURE 2.

Angiogenic signal-mediated Vegfr1 induction is associated with increased H3K56 acetylation at its chromatin domain. A, Vegfr1 mRNA expression after starved YSECs were treated with FGF2/EGF for different time intervals (means ± S.E. of the mean for three independent experiments). B, ChIP analysis (mean of three independent experiments), showing the time course of H3acK56 incorporation at the ∼200-kb Vegfr1 locus in YSECs. The inset shows excellent correlation between Vegfr1 transcriptional induction and H3acK56 incorporation at the Vegfr1 promoter region. C, ChIP analysis (means ± S.E. of the mean for three independent experiments) showing no significant changes in H3acK56 levels at the promoter regions of housekeeping genes Polr2a and Rpl27 and neuronal-specific gene Necdin in FGF2/EGF-treated starved YSECs.