FIGURE 8.
SEDI antibody specifically recognizes aggregates formed from holo SOD1. Specific SEDI binding to aggregated (SODagg) or nonaggregated (SODunagg) pWT was measured using competition of the C-terminal peptide epitope (see “Experimental Procedures”). C represents the control with SOD1 omitted. The recognition of aggregates relative to control is significant (**, p < 0.05), but there is no difference for nonaggregated protein relative to control (*, p > 0.1). The plotted values are the means ± S.D. for three independent aggregation experiments, for which sample measurements were made at least in duplicate.