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. 2010 Oct 11;285(53):42001–42012. doi: 10.1074/jbc.M110.166967

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© 2010 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 3. — Differential stability of sciatic nerve myelin for the various genotypes, depicted as myelin period versus pH. A, WT, P0(+/−), P0(−/−); B, S63C(+/+), S63C(+/−), S63C(−/−). The nerves were incubated in solutions ranging in pH from 6.0 to 8.0 and at native ionic strength (154 mm). The different symbol sizes indicate the relative amount of myelin having that particular period. The long arrows pointing from the native-like period to the swollen period indicate the pH range at which the structural transition occurred. In WT, the shift was at pH 6.5–7.0, whereas in S63C(+/−), it occurred at pH 7.5–8.0. The difference suggests more alkaline pH is needed to stabilize the S63C(+/−) than the WT myelin. The dashed lines are the linear regressions for the P0(−/−) and S63C(−/−) data; and the standard errors for the periodicity were 7.1 Å for P0(−/−) and 2.6 Å for S63C(−/−).