TABLE 2.
Time | Dimensions |
Δ/d | Myelin | M/(M+B) | |||
---|---|---|---|---|---|---|---|
d | cyt | lpg | ext | ||||
Å | % | ||||||
WT | |||||||
10 min | 174.7 | 31 | 48 | 47 | 0.023 | 0.38 | |
5 h | 174.7 | 31 | 48 | 47 | 0.023 | 0.42 | |
20 h | 174.7 | 31 | 48 | 47 | 0.023 | 0.41 | |
S63C(+/+) | |||||||
10 min | 175.3 | 31 | 49 | 46 | 0.023 | 0.30 | |
5 h | 175.1 | 31 | 49 | 46 | 0.023 | 0.31 | |
20 h | 174.4 | 30 | 49 | 46 | 0.023 | 0.29 | |
S63C(+/−) | |||||||
10 min | 175.9 | 33 | 47 | 49 | 0.028 | 0.23 | |
5 h | 175.9 | 33 | 47 | 49 | 0.023 | 95 | 0.27 |
196.5 | 5 | ||||||
20 h | 174.7 | 31 | 47 | 49 | 0.029 | 88 | 0.25 |
220.5 | 12 | ||||||
S63C(−/−) | |||||||
10 min | 206.0 | 0.049 | 0.14 | ||||
5 h | 208.4 | 0.048 | 0.15 | ||||
20 h | 205.4 | 0.054 | 0.21 | ||||
P0(+/−) | |||||||
10 min | 179.5 | 33 | 48 | 50 | 0.028 | 0.29 | |
5 h | 180.6 | 33 | 50 | 48 | 0.028 | 0.27 | |
20 h | 181.9 | 34 | 49 | 50 | 0.033 | 79 | 0.21 |
204.6 | 21 | ||||||
P0(−/−)a | |||||||
20 min | 191.2 | 0.037 | 0.10 | ||||
5 h | 191.7 | 0.042 | 0.09 |
a P0(−/−) sciatic nerve was too weak to withstand lengthy perfusion, so only data at 5 h are shown.