Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2010 Oct 27;285(53):42105–42114. doi: 10.1074/jbc.M110.172098

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2010 by The American Society for Biochemistry and Molecular Biology, Inc.

PMC Copyright notice

FIGURE 2. — Effect of NB-DNJ on stability of the GCase/SapC interface. A, ΔRMSF/RMSF_WT between WT and N370S at pH 4.5 with (black) and without (red) NB-DNJ+. Predicted interaction sites with SapC are highlighted in gray (39). Positive values indicate increased flexibility for N370S; negative values decreased flexibility. B, GCase surface color-coded for RMSF changes between WT and N370S. Blue patches, decreased flexibility for N370S; red patches, increased flexibility for N370S; orange patches, residues with increased flexibility for N370S that are part of the GCase/SapC interface; green patches, residues with decreased flexibility for N370S that are part of the GCase/SapC interface; yellow patches, residues that are part of the GCase/SapC interface and show no change in flexibility for N370S. The active site is colored pink. Residue numbers for each altered surface patch are given.