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. 2011 Jan 5;100(1):144–153. doi: 10.1016/j.bpj.2010.11.004

Figure 1.

Figure 1

(A) Crystal structure of RT-EFV complex (1IKW). Four subdomains of the polymerase domain in p66 and p51 subunits: (blue) fingers, (red) palm, (green) thumb, and (orange) connection. Faded colors indicate subdomains of p51 subunit. The RNase H domain of p66 subunit is shown in magenta. Balls show: (black) efavirenz; (pink) polymerase and RNase H active sites; and (cyan) polymerase and RNase H primer grips. (B) Allosteric network in RT. Balls show: (dark blue) efavirenz binding region; (cyan) region 1; (magenta) region 2; (green) region 3; (orange) region 4; (yellow) region 5. (pale blue) Peptides with the same H/D exchange in presence and absence of efavirenz and (white) missing coverage. Figure made using PyMOL (52).