Figure 1.

Comparison between the interaction network obtained in the Lieberman-Aiden et al (2009) experiment and a randomized interaction network. (A) Schematic drawing of an interaction network: nodes represent interacting fragments and each link between two nodes corresponds to one interaction read. (B) Distribution (Log10 scale) of the number of reads obtained between each pair of nodes in the actual data (red triangles) and in a randomized network (green dots, error bars correspond to a 95% confidence interval computed on 100 random networks). The statistical difference between those two distributions was assessed using the Kolmogorov–Smirnov test on the same plot normalized by the total number of interaction pairs. The obtained P-value was lower than 2.2 × 10^–16.