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. 2010 Nov 30;6:439. doi: 10.1038/msb.2010.94

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Copyright © 2010, EMBO and Macmillan Publishers Limited

This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial Share Alike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission.

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3PHP from serine biosynthesis can be used to supply 4PHT when the PLP synthesis pathway is blocked. Abbreviations: 3PG, 3-phosphoglycerate; 3PHP, 3-phosphohydroxypyruvate; SerP, 3-phospho-L-serine; Ser, L-serine; 3HP, 3-hydroxypyruvate; GA, glycolaldehyde; 4HT, 4-hydroxy-L-threonine; 4PHT, 4-phosphohydroxy-L-threonine; hSer, L-homoserine; hSerP, O-phospho-L-homoserine; PLP, pyridoxal-5′-phosphate; YeaB (NudL), predicted NUDIX hydrolase; ThrB, homoserine kinase; LtaE, low-specificity threonine aldolase; PdxB, erythronate-4-phosphate dehydrogenase; PdxA.