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A, changes of spark frequency and [Ca2+]SR after SERCA inhibition with TG (10 μm) in myocyte from failing hearts. B, the total (circles) and RuR-insensitive (squares) SR Ca2+ leak as a function of [Ca2+]SR in normal (black) and in HF myocytes (red). C, Ca2+ spark frequency in normal and HF myocytes measured at the same [Ca2+]SR (680 μm).
