Table II.
Baseline characteristics of lung cancer cases and controls nested within the PLCO Cancer Screening Trial
Characteristic at the time of blood collection | Controls (n = 117), N % |
Cases (n = 117), N % |
P-value | ||
Age in yearsa | |||||
55–64 | 30 | 25.6 | 30 | 25.6 | 1.00 |
65–69 | 37 | 31.6 | 37 | 31.6 | |
70–79 | 50 | 42.7 | 50 | 42.7 | |
Gendera | |||||
Male | 81 | 69.2 | 81 | 69.2 | 1.00 |
Female | 36 | 30.8 | 36 | 30.8 | |
Cigarette smoking statusa | |||||
Never smoked cigarettesb | 7 | 6.0 | 7 | 6.0 | 1.00 |
Quit 10+ years ago and cigarettes/day ≤ 1 pack | 8 | 6.8 | 8 | 6.8 | |
Quit 10+ years ago and cigarettes/day > pack | 27 | 23.1 | 27 | 23.1 | |
Current or quit <10 years ago and cigarettes/day ≤ 1 pack | 39 | 33.3 | 39 | 33.3 | |
Current or quit <10 years ago and cigarettes/day > 1 pack | 36 | 30.8 | 36 | 30.8 | |
Race | |||||
White, non-Hispanic | 112 | 95.7 | 109 | 93.2 | |
Nonwhite or Hispanic | 5 | 4.3 | 8 | 6.8 | 0.39 |
Education | |||||
≤11 years | 12 | 10.3 | 13 | 11.1 | 0.70 |
12 years or completed high school | 23 | 19.7 | 28 | 23.9 | |
Post-high school other than college or some college | 41 | 35.0 | 43 | 36.8 | |
College graduate or postgraduate | 41 | 35.0 | 33 | 28.2 | |
Lung cancer reported in first-degree relativesc | |||||
No | 97 | 84.3 | 98 | 84.5 | 0.64 |
Yes | 15 | 13.0 | 13 | 11.2 | |
Unknown | 3 | 2.6 | 5 | 4.3 | |
History of emphysemac | |||||
No | 104 | 92.0 | 96 | 88.9 | 0.43 |
Yes | 9 | 8.0 | 12 | 11.1 | |
Months between blood collection and lung cancer diagnosis | NA | ||||
3–11 | NA | 24 | 20.5 | ||
12–23 | NA | 28 | 23.9 | ||
24–35 | NA | 26 | 22.2 | ||
36–47 | NA | 24 | 20.5 | ||
48+ | NA | 15 | 12.8 | ||
Lung cancer histology | |||||
Adenocarcinoma | NA | 39 | 33.3 | NA | |
Squamous | NA | 27 | 23.1 | ||
Small cell | NA | 21 | 17.9 | ||
Non-small cell, not otherwise specified | NA | 8 | 6.8 | ||
Large cell | NA | 7 | 6.0 | ||
Otherd | NA | 15 | 12.8 |
NA is not applicable.
Matching variables.
Two cases and one control reported having smoked cigars but not cigarettes.
May not sum to 117 cases or 117 controls due to missing data.
Four cases bronchioalveolar adenocarcinoma, two cases acinar adenocarcinoma, two cases carcinoma not otherwise specified, one case intermediate cell carcinoma, one case adenosquamous carcinoma and five cases not available.