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. Author manuscript; available in PMC: 2010 Dec 27.
Published in final edited form as: Physiology (Bethesda). 2010 Feb;25(1):41–49. doi: 10.1152/physiol.00033.2009

FIGURE 4. Auxiliary and accessory subunits of ionotropic glutamate receptors.

FIGURE 4

Ionotropic glutamate receptors are pharmacologically classified as AMPA-, NMDA-, and kainate-sensitive glutamate receptors. Several transmembrane subunits have been proposed to date, but remain unconfirmed. The NMDAR complex comprises Neto1, which is a CUB domain-containing protein. The AMPAR complex comprises TARPs and cornichon. Notably, it remains unclear whether AMPAR/TARP/cornichon form a tripartite complex. The C. elegans AMPAR complex comprises SOL-1, which is a CUB domain-containing protein. Therefore, mammalian AMPAR complexes may comprise a mammalian homolog of SOL-1 (mSOL). The kainate receptor complex comprises Neto2, which is a CUB domain-containing protein. The high sequence homology between Neto1 and 2 raises the question of whether Neto1 and 2 act as auxiliary subunits for both NMDA and kainate receptors.