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. Author manuscript; available in PMC: 2011 Oct 29.
Published in final edited form as: Circ Res. 2010 Sep 2;107(9):1106–1116. doi: 10.1161/CIRCRESAHA.110.221069

Figure 5. Sensitization to col(V) results in exacerbated atherosclerotic disease.

Figure 5

ApoE−/− mice were i.v. treated with 8 doses of 50 μg col(V) at biweekly intervals or were left untreated; all were fed regular chow for 15 weeks. A, Representative H&E stained (40×), CD68 macrophage stained (200X), lipid stained (Oil Red O - 200X), and complement C3d stained (200X) aortic root sections. P-plaque, M-media, and A-adventitia. B, Quantitative analysis of total plaque area was performed on aortic roots taken at age 22 weeks. Each data point represents the mean value of total lesion area from 3 serial aortic sinus sections (n=10 mice per group). C, Serum samples were analyzed for col(V)-specific antibodies (n=10 in each group). Horizontal bars represent mean value for each group. Mann-Whitney p value for comparison is shown.