Fig. 11.

Effect of sampling frequency of noisy pseudodata on simultaneous estimates of flow (A), V_SV (B), and V_LV (C). Values are means ± SD of fits of 75 independent realizations of noisy pseudodata. Estimates from 2 sets of pseudodata are shown. For ●, true value (horizontal line) was flow = 2 ml·min⁻¹·g⁻¹. For ◆, flow = 1 ml·min⁻¹·g⁻¹. For both sets, V_SV = 0.11 ml/g and V_LV = 0.028 ml/g. Estimates of V_SV were indistinguishable in both sets of pseudodata (only 1 set is shown). For both flow rates, variability increased markedly with sampling frequencies of <2 samples/s, and flow was systematically overestimated with frequencies below ~1 sample/s.