Fig. 5.

Effect of changes in flow (ml·min⁻¹·g⁻¹), small vessel volume (V_SV, ml/g), and large vessel volume (V_LV, ml/g) on model fits (curves) of regional myocardial indicator content-time curve (○) obtained by MRI after bolus injection of polylysine-Gd-DTPA. In A–C, only 1 parameter was altered. Measured left ventricular blood pool curve (not shown) was used as model input. Changes in flow and V_SV had distinct effects on waveform of solution, although there were similar features in effects of flow and V_LV. If ≥2 parameters have identical effects on model solution, then they cannot be independently estimated.