Fig. 8.

Effect of random noise on optimized model fits to “pseudodata”: residue curves generated by model at a frequency of 1.25 samples/s with use of known (“true”) parameter values of flow = 0.8 ml·min⁻¹·g⁻¹, V_SV = 0.085 ml/g, and V_LV = 0.025 ml/g. Random uniform noise with a mean of zero was added to noise-free pseudodata (●) to obtain noisy pseudodata (○). Optimized model fits to noisy pseudodata obtained using very different parameter starting values (flow = 4 ml·min⁻¹·g⁻¹, V_SV = 0.15 ml/g, and V_LV = 0.029 ml/g, upper starting solution; flow = 0.1 ml·min⁻¹·g⁻¹, V_SV = 0.055 ml/g, and V_LV = 0.015 ml/g, lower starting solution) converged to identical final solution (continuous curve) of flow = 0.71 ml·min⁻¹·g⁻¹, V_SV = 0.080 ml/g, and V_LV = 0.020 ml/g. Final solution differs somewhat from true values because of effects of noise.