Table 3.

Location and magnitude of maximally significant regional-to-whole brain FDG uptake increases in AD-affected brain regions in APOEε4 carriers with the protective GAB2 haplotype than those without this haplotype

Brain Region	Atlas coordinates (mm)^a (X,Y,Z)	Z-score	P-value^b
Temporal (right)	(52, −48, −2)	2.65	0.004
Temporal (left)	(−40,−62, 20)	3.60	0.0001^c
Parietal 1 (right)	(56, −18, 44)	3.29	0.001
Parietal 1 (left)	(56, −42,− 32)	--^d	0.002
Parietal 2 (left)	(−26,−60, 46)	2.82	0.002
Parietal 2 (right)	(50, −32, 53)	-- ^d	0.0009
Occipital (left)	(−38,−64, 22)	3.49	0.0002

The coordinates were obtained from (Tournoux, 1988). X is the distance to the right (+) or left (−) of the midline, Y is the distance anterior (+) or posterior (−) to the anterior commissure, and Z is the distance superior (+) or inferior (−) to a horizontal plane through the anterior and posterior commissures.

The reported significance level is one-tailed and uncorrected for multiple comparisons.

Remains significant after correction for multiple comparisons.

No voxel survived small-volume correction.