TABLE 5.
Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for non-small cell lung cancer stratified by smoking status
| Never | Former | Current | |||||
|---|---|---|---|---|---|---|---|
| Cases/controls | OR1 (95% CI) | Cases/controls | OR1 (95% CI) | Cases/controls | OR1 (95% CI) | P-interaction | |
| Age at menarche | |||||||
| <12 | 8/33 | 1.00 (Reference) | 32/40 | 1.00 (Reference) | 45/36 | 1.00 (Reference) | |
| 12-13 | 25/111 | 0.87 (0.33, 2.28) | 83/146 | 0.65 (0.37, 1.14) | 115/79 | 1.16 (0.67, 2.01) | |
| 14-15 | 7/33 | 1.02 (0.30, 3.51) | 33/46 | 0.74 (0.37, 1.47) | 52/44 | 0.83 (0.45, 1.55) | |
| ≥16 | 2/4 | 0.84 (0.10, 6.81) | 13/25 | 0.56 (0.24, 1.32) | 15/14 | 0.80 (0.33, 1.94) | 0.77 |
| Menopausal status2 | |||||||
| Natural menopause at age <50 | 7/22 | 1.35 (0.37, 4.92) | 32/42 | 1.32 (0.67, 2.60) | 68/35 | 1.67 (0.86, 3.24) | |
| Natural menopause at age 50-54 | 7/44 | 1.00 (Reference) | 29/53 | 1.00 (Reference) | 32/32 | 1.00 (Reference) | |
| Natural menopause at age ≥55 | 4/13 | 2.09 (0.47, 9.26) | 20/28 | 1.32 (0.61, 2.85) | 5/10 | 0.45 (0.13, 1.52) | 0.15 |
| Number of live births | |||||||
| Nulliparous | 9/19 | 1.65 (0.54, 5.04) | 17/25 | 1.04 (0.50, 2.18) | 19/15 | 1.12 (0.52, 2.42) | |
| 1-2 | 6/48 | 1.00 (Reference) | 40/86 | 1.00 (Reference) | 99/68 | 1.00 (Reference) | |
| 3-4 | 14/69 | 0.62 (0.23, 1.65) | 63/97 | 0.68 (0.42, 1.10) | 73/64 | 0.71 (0.43, 1.16) | |
| ≥ 5 | 13/45 | 0.26 (0.06, 1.07) | 41/49 | 0.48 (0.24, 0.99) | 36/26 | 0.54 (0.28, 1.05) | 0.58 |
| Age at first birth | |||||||
| Nulliparous | 9/19 | 3.11 (0.78, 12.31) | 17/25 | 1.70 (0.77, 3.76) | 19/15 | 1.10 (0.50, 2.42) | |
| <20 | 20/72 | 1.00 (Reference) | 74/104 | 1.00 (Reference) | 114/78 | 1.00 (Reference) | |
| 20-24 | 10/56 | 1.32 (0.43, 4.07) | 54/90 | 1.34 (0.78, 2.30) | 66/54 | 0.69 (0.42, 1.13) | |
| ≥25 | 3/34 | 1.88 (0.57, 6.17) | 16/38 | 1.67 (0.88, 3.18) | 28/26 | 0.83 (0.43, 1.57) | 0.13 |
| Age at last birth | |||||||
| Nulliparous | 9/19 | 1.37 (0.34, 5.61) | 17/25 | 1.27 (0.58, 2.78) | 19/15 | 1.12 (0.51, 2.47) | |
| <25 | 7/27 | 1.00 (Reference) | 39/73 | 1.00 (Reference) | 81/57 | 1.00 (Reference) | |
| 25-29 | 13/56 | 0.76 (0.23, 2.46) | 51/62 | 1.37 (0.77, 2.42) | 64/48 | 0.83 (0.49, 1.41) | |
| ≥30 | 13/79 | 0.49 (0.15, 1.59) | 54/97 | 0.69 (0.39, 1.22) | 63/53 | 0.71 (0.42, 1.20) | 0.53 |
| Oral contraception | |||||||
| Never user | 21/97 | 1.00 (Reference) | 99/142 | 1.00 (Reference) | 114/87 | 1.00 (Reference) | |
| Ever user | 21/84 | 1.71 (0.66, 4.45) | 62/115 | 1.24 (0.76, 2.02) | 113/86 | 1.22 (0.77, 1.92) | 0.62 |
| Menopausal hormone therapy | |||||||
| Never used | 18/85 | 1.00 (Reference) | 80/121 | 1.00 (Reference) | 138/94 | 1.00 (Reference) | |
| Ever used | 24/96 | 1.42 (0.62, 3.26) | 81/136 | 0.95 (0.61, 1.47) | 89/79 | 0.88 (0.57, 1.35) | 0.72 |
| Ever used estrogen plus progestin pills3 | 3/9 | 1.74 (0.34, 8.82) | 11/18 | 1.20 (0.49, 2.94) | 7/5 | 1.09 (0.32, 3.69) | 0.83 |
| Ever used estrogen pills3,4 | 7/34 | 0.31 (0.05, 2.03) | 25/46 | 0.78 (0.35, 1.74) | 34/34 | 0.72 (0.35, 1.49) | 0.64 |
1
Conditioned on age and race and adjusted for age, education, smoking, number of smoking adults in household, current household income
2
Also adjusted for premenopause, hysterectomy/ovaries removed, hysterectomy/ovaries removed or unknown if ovaries removed, other reasons for having menopause
3
Excludes women who reported ever using a different type of menopausal hormone therapy
4
Among women who ever had a hysterectomy (n=434); reference group is 6/23 never smokers, 25/46 former smokers, and 46/30 current smokers who never used menopausal hormones