Table 5.

Variance Sources and Consequences: Metrifonate vs. Phenserine CTs

Variance Components	Metrifonate*-2 3mo./6mo.	Phenserine*-2 3mo./6mo.
Individual Severity- Fixed	Yes MMSE 10-26	Yes MMSE 8-24
Inter-site- Variable	Not Applicable	Yes Est. SD = 4.5 (129%-MMSE)
Intra-site- Variable	Not Applicable	Yes Est. SD =100-170%
4. Temporal- Fixed	No	No
5. Intervention- Fixed	Var. Increased.	Var. Increased.
6. Random Measurement Error Variance-Variable	+/−2.5 for Means of 3 Observations	+/−4.5 (180%) for Single Observations
Sample Size	50/50	75/215
Drug-Placebo Differ- p = Variable	p = <0.01/<0.03	p = n.s./n.s.
CT Costs- Variable	$	$$$$$$-Cases Cost

^*The 3 and 6 month CTs for metrifonate and the other ACHEI phenserine were matched for mean differences between actively and placebo treated arms.