Table 4.

Estimated Teratogenic Events per 1,000 HIV-infected Women

	Teratogenic Events per 100,000 HIV-infected Women	Excess Events per 100,000 HIV-infected Women
Base Case
Age-adjusted Pregnancy Rate: 7.4 pregnancies per 100 person-years
No efavirenz exposure	72.46
With efavirenz exposure	77.26	4.80
Sensitivity Analysis Results
Age-specific Pregnancy Rates
Ages 15-24 years: 18.1 pregnancies per 100 person-years
No efavirenz exposure	177.24
With efavirenz exposure	188.96	11.73
Ages 25-34 years: 6.5 pregnancies per 100 person-years
No efavirenz exposure	63.65
With efavirenz exposure	67.86	4.21
Ages 35-44 years: 1.4 pregnancies per 100 person-years
No efavirenz exposure	13.71
With efavirenz exposure	14.62	0.91
Live Birth Rate (base case: 36%)
Live birth rate: 27%
No efavirenz exposure	54.35
With efavirenz exposure	57.94	3.60
Live birth rate: 45%
No efavirenz exposure	90.58
With efavirenz exposure	96.57	5.99
Sensitivity Analysis on Rates of Teratogenic Events Among HIV-Infected Women
Prevalence of Teratogenic Events with Efavirenz (base case: 2.9%)
Lower Bound of the 95% Confidence Interval for the Mean (1.6%)
No efavirenz exposure	72.46
With efavirenz exposure	42.62	−29.84
Upper Bound of the 95% Confidence Interval for the Mean (4.9%)
No efavirenz exposure	72.46
With efavirenz exposure	130.54	58.08
Prevalence of Teratogenic Events without Efavirenz (base case: 2.72%)
Lower Bound of the 95% Confidence Interval for the Mean (2.68%)
No efavirenz exposure	71.40
With efavirenz exposure	77.26	5.86
Upper Bound of the 95% Confidence Interval for the Mean (2.76%)
No efavirenz exposure	73.53
With efavirenz exposure	77.26	3.73