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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Bioorg Med Chem Lett. 2010 Nov 5;21(1):338–341. doi: 10.1016/j.bmcl.2010.11.004

Table 3.

Cytotoxic activity of synthesized PT compounds

Compound IC50a(μM)±SD for cancer cell lines
PC3 A549 MCF-7 HeLa BGC-823
5 6.75±0.57 136.1±10.1 559.6±45.5 N/Ab N/Ab
6 5.32±0.43 996.5±80.7 373.6±23.7 17.1±0.9 9.54±0.78
8 NAb 770.1±65.6 397.5±15.8 NAb 19.3±1.66
9 NAb 892.5±46.8 565.3±22.4 NAb NAb
10 66.3±5.56 62.9±5.69 603.5±44.5 63.1±2.8 25.9±1.49
11 8.51±0.73 194.2±10.6 32.5±2.79 105.4±11.2 12.7±0.85
12 10.8±0.08 0.89±0.07 0.33±0.04 56.7±4.9 7.64±0.19
1 19.7±1.55 16.8±2.13 87.2±8.46 19.1±2.1 2.41±0.22
Adriamycinc 0.68±0.07 0.54±0.04 1.65±0.11 1.35±0.08 1.33±0.09
a

Values are means of three experiments.

b

NA = no activity.

c

Adriamycin was used as a positive control.