Table 2.
Kidney gene expression
| STZ | Control | P (ANOVA) | |||||
|---|---|---|---|---|---|---|---|
| −LA | +LA | −LA | +LA | STZ | LA | Interaction | |
| nephrin | 0.44±0.16 (5) |
0.92±0.17 (4) |
1.00±0.12 (12) |
0.98±0.18 (12) |
<0.05 | <0.05 | 0.65 |
| tgfβ1 | 1.65±0.12 (15) |
1.04±0.07 (13) |
1.00±0.19 (13) |
0.91±0.19 (12) |
<0.01 | <0.05 | 0.70 |
| ctgf | 1.55±0.13 (15) |
1.05±0.11 (13) |
1.00±0.16 (13) |
0.83±0.07 (12) |
<0.05 | <0.05 | 0.91 |
| Col1 | 1.22±0.16 (15) |
0.93±0.12 (15) |
1.00±0.19 (13) |
1.11±0.04 (12) |
NA | NA | 0.78 |
| Col4 | 1.15±0.10 (15) |
1.02±0.84 (15) |
1.00±0.12 (13) |
0.85±0.29 (12) |
NA | NA | 0.11 |
| RAGE | 2.47±0.48 (12) |
1.13±0.37 (12) |
1.00±0.24 (12) |
0.94±0.11 (12) |
<0.05 | <0.05 | 0.23 |
| SOD2 | 0.69±0.14 (12) |
0.98±0.07 (13) |
1.00±0.14 (12) |
0.92±0.09 (12) |
<0.01 | <0.01 | 0.24 |
| eNOS | 1.88±0.68 (15) |
1.10±0.65 (15) |
1.00±0.16 (12) |
0.87±0.12 (12) |
NA | NA | 0.31 |
| P22phox | 1.60±0.15 (12) |
1.02±0.17 (12) |
1.00±0.13 (12) |
0.88±0.11 (12) |
<0.05 | NA | 0.09 |
| p47phox | 1.92±0.15 (12) |
1.07±0.13 (12) |
1.00±0.27 (12) |
0.86±0.08 (12) |
<0.05 | <0.05 | 0.07 |
| GPX1 | 0.78±0.14 (15) |
1.26±0.46 (12) |
1.00±0.16 (12) |
1.21±0.26 (11) |
NA | NA | 0.93 |
| Lias | 0.27±0.03 (15) |
0.19±0.02 (13) |
1.00±0.14 (12) |
0.70±0.11 (12) |
<0.001 | <0.05 | 0.23 |
| Pdp2 | 0.27±0.06 (12) |
0.74±0.10 (12) |
1.00±0.12 (12) |
1.34±0.21 (12) |
<0.001 | <0.01 | 0.88 |
| Pdk4 | 0.79±0.21 (12) |
0.89±0.23 (12) |
1.00±0.30 (9) |
1.13±0.19 (9) |
NA | NA | 0.96 |
mRNA levels in kidney cortex are expressed as mean ± SE relative to the mean levels of the control without LA as 1.00. The numbers of animals are in the parentheses.