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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: J Inorg Biochem. 2010 Sep 22;105(3):467–475. doi: 10.1016/j.jinorgbio.2010.08.011

Figure 6.

Figure 6

Proposed QN-FPIX adduct structure. The model involves coordination between the –OH group of QN and Fe of FPIX, aided by the formation of a strong hydrogen bond between the –OH proton and the quinuclidyl nitrogen, resulting in the formation of a five-membered ring. Note also that in this model the quinoline ring is tilted away from porphyrin ring system resulting in minimal π- π interactions. Further, the methoxy group of QN is oriented in such a way as to be spatially close to the vinyl group as observed in NOESY experiments with ZnPIX (data not shown).