Table 3.
Replication and combined results of rs3219125 and rs13091637 on melanoma risk
| Genotype | Discovery Set (n = 436) | Replication Set 1, HPFS (n = 368) | Replication Set 2, NHS (n = 366) | Joint Analysis (n =1170 ) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Case (n = 218) | Control (n = 218) | ORa (95% CI) | Case (n=184) | Control (n = 184) | ORa (95% CI) | Case (n=183) | Control (n = 183) | ORa (95% CI) | ORb (95% CI) | Adjusted ORc (95% CI) | |
| PARP1 rs3219125 | |||||||||||
| AA | 169 | 189 | 1(ref) | 147 | 163 | 1(ref) | 158 | 157 | 1(ref) | 1(ref) | 1(ref) |
| AG/GG | 44 | 16 | 3.14(1.70–5.80) | 33 | 19 | 1.92(1.05-3.54) | 25 | 23 | 1.07(0.58–1.97) | 1.89(1.34–2.68) | 1.67(1.16–2.42) |
| ATR rs13091637 | |||||||||||
| CC | 114 | 150 | 1(ref) | 119 | 117 | 1(ref) | 119 | 123 | 1(ref) | 1(ref) | 1(ref) |
| CT/TT | 95 | 59 | 2.12(1.41–3.18) | 58 | 60 | 0.94(0.60–1.46) | 62 | 57 | 1.12(0.72–1.73) | 1.34(1.05–1.72) | 1.38 (1.06–1.80) |
a
Adjusted by age
b
Adjusted by age and gender
c
Adjusted by age, gender, hair color, childhood tanning ability, moles on the arms, number of lifetime severe sunburn, and family history of melanoma in first-degree relatives.