Table 5.

Multivariable Predictors of Major Adverse Cardiac Events (MACE)

Predictor	Without AT activity information in model (n = 1403; r2 = 0.156)
	Odds ratio	95% confidence interval	P
Age
<55 yr	1.00	—
55–64 yr	1.26	0.72–2.21
65–74 yr	1.26	0.70–2.28
75–84 tears	1.66	0.86–3.20
≥85 yr	0.70	0.11–4.36	0.58
Gender (female)	1.13	0.72–1.78	0.60
Race (Caucasian)	0.59	0.36–0.95	0.03
Body mass index
<20	0.67	0.15–3.04
20–24.9	0.52	0.28–0.96
25–34.9	0.48	0.30–0.77
≥35	1.00	—	0.03
Institution	0.73	0.44–1.21	0.22
Myocardial infarction <2 wk prior	1.70	1.11–2.59	0.014
Prior peripheral vascular procedure	3.38	1.53–7.46	0.003
Perfusion time (10 min increment)	1.09	1.05–1.14	<0.0001
Concurrent other cardiac procedure	1.47	0.82–2.67	0.20
Preoperative or intraoperative IABP	4.02	2.18–7.42	<0.0001
RBC transfusion during hospital stay (per unit)	1.10	1.04–1.16	0.0004

Additional Predictive Value of AT Activity at Each Time Point Added to the Clinical Model
AT activity (0.1 IU/mL decrease)	Odds Ratio	95% Confidence interval	P value of AT variable	P value of improvement in overall model
Preoperative AT activity	0.98	0.85–1.13	0.7820	0.7822
Postoperative AT activity	1.10	0.91–1.31	0.3193	0.3179
POD 1 AT activity	1.13	0.96–1.33	0.1565	0.1543
POD 2 AT activity	1.26	1.07–1.48	0.0056	0.0053
POD 3 AT activity	1.19	1.01–1.41	0.0412	0.0399
POD 4 AT activity	1.17	1.00–1.37	0.0506	0.0493
POD 5 AT activity	1.17	1.00–1.37	0.0553	0.0546
Change in AT activity Post-CPBa	1.15	0.93–1.41	0.1888	0.4058
Change in AT activity Day 1a	1.20	1.00–1.45	0.0558	0.1394
Change in AT activity Day 2a	1.36	1.13–1.62	0.0009	0.0035
Change in AT activity Day 3a	1.26	1.04–1.52	0.0163	0.0525
Change in AT activity Day 4a	1.26	1.06–1.51	0.0104	0.0294
Change in AT activity Day 5a	1.20	1.01–1.44	0.0407	0.1201

^aRefers to change in AT activity from the baseline level.

AT = antithrombin; RBC = red blood cell; POD = postoperative day.