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. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: Curr Opin Struct Biol. 2010 Oct 21;20(6):739–748. doi: 10.1016/j.sbi.2010.09.006

Figure 3.

Figure 3

Different relative orientations of the PHD and JmjC domains in PHF8 and KDM7A. (a) Structure of the PHD and core catalytic domains of human PHF8 bound to an H3 peptide containing both H3K4me3 and H3K9me2 (PDB code 3KV4). The PHD and the catalytic core domains of PHF8 are colored pink and gray, respectively. The H3 peptide is green. (b) Structure of C. elegans KDM7A bound to two different H3 molecules each containing both H3K4me3 and H3K9me2 (PDB code 3N9N). The PHD and the catalytic core domains of PHF8 are colored pink and gray, respectively. The H3 peptide is green. The position of the catalytic core of KDM7A is shown in the same orientation as that of PHF8 in (a).