Figure 3.

An overview of the selectivity property of bioactive compounds in PubChem. a. the distribution of compounds’ across-target activity. X-axis represents the number of distinct active protein targets associated with a compound, while Y-axis represents the frequency of compounds at each across-activity level. It shows that majority compounds are associated with one or a few protein targets, and a small portion of them interact with a large amount of targets; b. the blue bars represent the distribution of the number of tested targets for selective compounds (only active to one protein target in PubChem). Compounds are divided into six selectivity groups. It suggests that the majority of the selective compounds have been tested across over 150 targets. The red bars denote the frequency of the protein targets associated with the compounds in the respective selectivity group.