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. Author manuscript; available in PMC: 2010 Dec 27.
Published in final edited form as: Sci Transl Med. 2010 May 26;2(33):33ra37. doi: 10.1126/scitranslmed.3001006

Figure 5. TCA intermediate changes with marathon running.

Figure 5

(Left) Equally weighted-sums of absolute concentrations of TCA cycle intermediates (ΣTCAi, in mass spectrometry arbitrary units) (au) at baseline and upon completion of the marathon in groups of faster and slower runners (medians ± IQR). Span 1 TCA cycle intermediates include citrate/isocitrate, aconitic acid, and α - ketoglutarate. Span 2 TCA cycle intermediates include succinate, malate, and fumarate. *P=0.0001 vs. baseline. **P=0.004 between groups comparison.

(Right) Relative percent changes (medians ± IQR) in metabolites from span 1 and span 2 that account for observed differences between the two groups of runners. **P=0.005 for between groups comparison.