Table 2.

HPRT gene modification in human cells

Cell Type	Vector	MOI*	Fraction 6TGR
HT-1080	AAV-HPe2/3X	50,000	5.3 × 10−4
"	"	"	2.4 × 10−5
"	AAV-HPe2/3	"	<1.0 × 10−5
"	"	"	2.2 × 10−5
"	none	-	<1.4 × 10−5
"	"	-	1.0 × 10−5
MHF1	AAV-HPe2/3X	15,000	3.2 × 10−5
"	"	"	4.2 × 10−5
"	AAV-HPe2/3	"	6.3 × 10−5
"	"	"	<2.4 × 10−5
"	none	-	< 1.9 × 10−5
"	"	-	< 2.0 × 10−5
MHF2	AAV-HPe2/3X	15,000	2.6 × 10−3
"	"	"	8.8 × 10−5
"	AAV-HPe2/3	"	<2.2 × 10−5
"	"	"	2.4 × 10−5
"	none	-	2.2 × 10−5
"	"	-	<1.9 × 10−5
MHF3	AAV-HPe2/3X	15,000	7.3 × 10−4
"	"	"	6.4 × 10−4
"	AAV-HPe2/3	"	<2.8 × 10−5
"	"	"	<2.4 × 10−5
"	none	-	<2.6 × 10−5
"	"	-	<2.3 × 10−5

^*vector genomes per cell.