Table 2.

Adverse Events

Toxicity	Grade 1	Grade 2	Grade 3	Grade 4	Grade 5
N = 77	Number (%)	Number (%)	Number (%)	Number (%)	Number (%)
Leukocytes (Total WBC)	5 (6%)	18 (23%)	27 (35%)	23 (30%)	0
Neutrophils	4 (5%)	2(3%)	14 (18%)	39 (51%)	0
Platelets	27 (35%)	5 (6%)	2 (3%)	1 (1%)	0
Febrile Neutropenia	0 (0%)	0 (0%)	2 (3%)	1 (1%)	0
Documented Infections	0 (0%)	0 (0%)	8 (10%)	0 (0%)	0
Infection without neutropenia	2 (3%)	13 (17%)	3 (4%)	0 (0%)	1 (1%)
Cardiac Arrhythmia	3 (4%)	0 (0%)	5 (6%)	1 (1%)	0
Edema	20 (26%)	10 (13%)	3 (4%)	0 (0%)	0
Hypertension	8 (10%)	1 (1%)	3 (4%)	1 (1%)	0
Hypotension	0 (0%)	2 (3%)	2 (3%)	0 (0%)	0
PT Prolongation	7 (9%)	6 (8%)	6 (8%)	0 (0%)	0
Fatigue	15 (19%)	36 (47%)	15 (19%)	4 (5%)	0
Anorexia	16 (21%)	20 (26%)	2 (3%)	0 (0%)	0
Colitis	0 (0%)	1 (1%)	0 (0%)	1 (1%)	0
Constipation	15 (19%)	13 (17%)	3 (4%)	0 (0%)	0
Diarrhea	21 (27%)	15 (19%)	5 (6%)	0 (0%)	0
Dehydration	2 (3%)	4 (5%)	2 (3%)	0 (0%)	0
Ileus/Obstruction	0 (0%)	0 (0%)	4 (5%)	0 (0%)	0
Stomatitis/Mucositis	11 (14%)	16 (21%)	3 (4%)	0 (0%)	0
Nausea	32 (42%)	13 (17%)	4 (5%)	0 (0%)	0
Epistaxis	32 (42%)	0 (0%)	1 (1%)	0 (0%)	0
Hemorrhage	6 (8%)	0 (0%)	1 (1%)	0 (0%)	0
Melana/GI bleed	0 (0%)	0 (0%)	2 (3%)	0 (0%)	0
Transaminase (AST)	5 (6%)	3 (4%)	3 (4%)	0 (0%)	0
Acidosis	0 (0%)	0 (0%)	0 (0%)	0 (0%)	1 (1%)
Hypoalbuminemia	20 (26%)	10 (13%)	3 (4%)	0 (0%)	0
Hyperglycemia	11 (14%)	15 (19%)	3 (4%)	1 (1%)	0
Hypokalemia	6 (8%)	0 (0%)	2 (3%)	1 (1%)	0
Hyponatremia	13 (17%)	0 (0%)	5 (6%)	0 (0%)	0
CNS Ischemia	0 (0%)	0 (0%)	1 (1%)	1 (1%)	0
CNS Hemorrhage/Bleed	0 (0%)	0 (0%)	1 (1%)	0 (0%)	0
Mood alteration	8 (10%)	3 (4%)	3 (4%)	0 (0%)	0
Neuropathy	20 (26%)	14 (18%)	4 (5%)	0 (0%)	0
Syncope	0 (0%)	0 (0%)	4 (5%)	0 (0%)	0
Bone pain	1 (1%)	8 (10%)	4 (5%)	0 (0%)	0
Neuropathic pain	1 (1%)	1 (1%)	0 (0%)	1 (1%)	0
Pain	7 (9%)	16 (21%)	11 (14%)	0 (0%)	0
Cough	11 (14%)	1 (1%)	3 (4%)	0 (0%)	0
Dyspnea	0 (0%)	13 (17%)	3 (4%)	3 (4%)	0
Proteinuria	11 (14%)	5 (6%)	1 (1%)	0 (0%)	0
Thrombosis/Embolism	0 (0%)	0 (0%)	4 (5%)	2 (3%)	1 (1%)