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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Neurobiol Aging. 2010 Sep 20;33(5):979–990. doi: 10.1016/j.neurobiolaging.2010.07.022

Figure 2.

Figure 2

Aging does not alter the pattern of Arc expression in pyramidal cells of CA1 or CA3. (A) Representative confocal images (scale bar = 60 μm) demonstrate that two exploration sessions separated by 480 minutes induce a robust increase in the number of pyramidal cells that express Arc in CA1 (left) and CA3 (right) in both young (top) and aged (middle) animals relative to caged controls (bottom). No significant differences in Arc expression were observed between young and aged, memory-impaired animals in either CA1 (B) and CA3 (C). Exploration induced a significant increase in the number of cells expressing intra-nuclear Arc (reflecting the second exploration occurring immediately prior to sacrifice) relative to caged controls in both age groups (all data are mean ± SEM; * p < 0.05, ** p < 0.01 vs. caged controls).

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