Table 1.
In vitro host range and replicative capacity of DURV and other selected rhabdoviruses.
| DURV | FARV | FLAV | KLAV | VSINV | |
|---|---|---|---|---|---|
| Vero | 6.68 (3)a | 9.15 (2) | 5.73 (2) | 7.63 (4) | 9.20 (2) |
| CPAE | 5.67 (2) | 7.60 (3) | nd | 6.67 (6) | 8.06 (2) |
| Tb 1 Lu | 5.24 (3) | 7.62 (3) | nd | 4.26 (4) | 7.27 (5) |
| PDE | ndb | 7.63 (2) | nd | 4.20 (3) | 6.42 (5)c |
| QNR/K2 | 6.72 (4) | 8.33 (3) | nd | nd | 7.55 (2) |
| C6/36 | nd | nd | 3.30 (4) | nd | nd |
| FHM | nd | 6.94 (3) | nd | nd | nd |
| TH-1 | nd | 6.89 (3) | nd | nd | 8.63 (3) |
| VH-2 | nd | nd | nd | nd | 7.58 (5) |
Maximum titers (log10 PFU/mL) reached over the 8-day growth period are given, followed by the day at which the maximum titer was reached in parentheses.
nd, not detected above input level; i.e., maximum titer recovered never exceeded the initial inoculum/mL.
PDE cells were essentially non-permissive to VSINV infection, as previously reported by Levinson et al. (1978); titer given at day 5 represents the single well of eight in which a titer above the initial inoculum was recorded. Nucleotide sequencing of the G protein from the initial inoculum versus virus harvested on day 5 did not disclose any nucleotide substitutions, suggesting adaptation of VSINV to PDE cells was not at the level of receptor binding.