Table 1.
Parameter | Overnight fasted/re-fed in light phase |
Fedad libitumin dark phase | ||||
---|---|---|---|---|---|---|
Vehicle | Ucn 2 (10 µg/kg) |
Vehicle | Ucn 2 (10 µg/kg) |
Vehicle | Ucn 2 (30 µg/kg) |
|
Meal frequency (number/4h) |
2.38 ± 0.56 | 4.25 ± 0.56* | 4.86 ± 0.74 | 4.86 ± 0.67 | 4.86 ± 0.67 | 4.13 ± 0.29 |
Meal size (g/meal) | 0.82 ± 0.12 | 0.24 ± 0.03*** | 0.14 ± 0.01 | 0.13 ± 0.02 | 0.17 ± 0.01 | 0.10 ± 0.01*** |
Meal duration (min) |
74.49 ± 14.88 | 22.56 ± 2.93** | 16.67 ± 2.70 | 14.86 ± 1.94 | 16.84 ± 1.20 | 11.32 ± 0.77** |
Feeding bouts (number/4h) |
25.88 ± 2.24 | 21.38 ± 2.50 | 22.14 ± 5.82 | 26.00 ± 6.42 | 22.57 ± 2.75 | 18.75 ± 1.96 |
Total meal time (min/4h) |
130.18 ± 6.53 | 88.24 ± 9.34** | 84.85 ± 19.38 | 72.50 ± 13.28 | 77.91 ± 6.66 | 45.80 ± 3.29*** |
Inter-meal interval (min) |
126.54 ± 23.85 | 56.45 ± 6.91* | 29.66 ± 6.30 | 33.96 ± 4.22 | 41.34 ± 6.32 | 40.23 ± 3.65 |
Time spent in meals (%/4h) |
54.24 ± 2.72 | 36.76 ± 3.89** | 35.35 ± 8.08 | 30.21 ± 5.54 | 32.46 ± 2.78 | 19.08 ± 1.37*** |
Latency to 1st meal (min) |
4.29 ± 0.81 | 5.38 ± 1.15 | 33.67 ± 13.36 | 44.70 ± 19.31 | 14.38 ± 8.14 | 68.34 ± 16.17* |
Duration 1st meal (min) |
87.38 ± 12.93 | 15.56 ± 3.33*** | 11.94 ± 3.00 | 11.58 ± 3.54 | 16.69 ± 3.19 | 8.48 ± 1.89* |
Eating rate 1st meal (mg/min) |
7.27 ± 1.59 | 4.77 ± 0.82 | 3.61 ± 1.28 | 3.31 ± 0.88 | 2.69 ± 0.65 | 1.74 ± 0.61 |
Eating rate/4h (mg/min) |
6.61 ± 1.48 | 4.01 ± 0.49 | 3.63 ± 0.56 | 3.08 ± 0.17 | 3.32 ± 0.42 | 2.33 ± 0.17* |
Satiety ratio (min/g) |
156.53 ± 14.20 | 239.54 ± 29.70* | 253.80 ± 74.03 | 282.09 ± 31.62 | 244.01 ± 33.79 | 419.12 ± 30.32** |
Each group had vehicle controls tested at the same time of Ucn 2 and also injected ip. Data are mean ± SEM; n=7–8 mice/group.
p < 0.05,
< 0.01,
< 0.001 vs. vehicle, respectively.