Table 1.
Heart rate (HR), QT interval (QT), mechanical systole (QLVPend) and electro-mechanical window (EMw) values in anaesthetized beagle dogs before and after pacing (A), isoprenaline (B), atropine (C) and during hypo-, normo- and hyperthermia (D)
| Treatment | n | HR (b.p.m.) | QT (ms) | QLVPend (ms) | EMw (ms) | ||
|---|---|---|---|---|---|---|---|
| A | Pacing | Baseline | 8 | 74 ± 10 | 231 ± 11 | 311 ± 12 | 80 ± 7 |
| 120 b.p.m. | 8 | 120 ± 0† | 209 ± 10† | 285 ± 14† | 76 ± 9 | ||
| B | Isoprenaline | Baseline | 5 | 97 ± 10 | 229 ± 7 | 320 ± 10 | 90 ± 7 |
| 2.5 µg·kg−1 | 5 | 191 ± 31† | 188 ± 13† | 193 ± 29† | 5 ± 28† | ||
| C | Atropine | Baseline | 5 | 71 ± 19 | 253 ± 10 | 356 ± 28 | 104 ± 31 |
| 10 µg·kg−1 | 5 | 205 ± 19† | 184 ± 6† | 251 ± 10† | 67 ± 16 | ||
| D | Body | 35.0°C | 4 | 60 ± 9 | 311 ± 34† | 409 ± 24† | 98 ± 33 |
| Temperature | 37.5°C | 8 | 65 ± 16 | 259 ± 23 | 347 ± 21 | 88 ± 18 | |
| 40.0°C | 8 | 81 ± 35 | 213 ± 23† | 296 ± 23† | 83 ± 12 |
Values are expressed as mean ± SEM; data were statistically tested against baseline (A, B and C), and in group D hypothermic (35.0°C) and hyperthermic (40.0°C) were tested against normothermic (37.5°C) dogs.
Intergroup comparisons:
†
P < 0.05; ANOVA/Dunnett's test (two-sided, unpaired).