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. 2010 Dec;161(7):1458–1471. doi: 10.1111/j.1476-5381.2010.00955.x

Figure 1.

Figure 1

Concentration–response curves to acetylcholine (ACh), phenylephrine and KCl obtained in aortic rings from normoglycaemic (control) or diabetic mice. The data are represented as mean ± SEM. (A) ACh-induced relaxation in diabetic and control vessels with functional endothelium (n = 8). (B) Contractile responses to phenylephrine in endothelium-containing (E+) or denuded (E−) aortic rings (n = 5); ***P < 0.001. (C) Concentration–response curves to phenylephrine in endothelium-containing vessels with or without indomethacin (n = 5) or (D) bosentan (n = 4). Concentration–response curves to phenylephrine (E) and KCl (F) in endothelium-containing vessels L-NAME (n = 4). ***P < 0.001.