Table 2.

Heart rate, QT and T_peak–T_end intervals, T-wave lability index and arterial blood pressure in anaesthetized rabbits

				Phenylephrine					Phe + Dof
	n	0 min	10 min	13 min	16 min	19 min	22 min	27 min	29 min	31 min
TdP−
HR	10	275 ± 10	275 ± 10	270 ± 10	255 ± 12	253 ± 13	242 ± 15	236 ± 12	229 ± 6	222 ± 23
QT	10	160 ± 4	167 ± 3	163 ± 4	172 ± 5	172 ± 6	184 ± 6	188 ± 7	196 ± 5	213 ± 14
TpTe	10		52 ± 5					58 ± 5		68 ± 7
TWLI	10		0.08 ± 0.02					0.08 ± 0.01	n.d.	n.d.
DAP	10	85 ± 5	94 ± 4	99 ± 5	105 ± 4	110 ± 5	114 ± 4	115 ± 3		126 ± 7
SAP	10	110 ± 4	117 ± 3	122 ± 5	129 ± 5	137 ± 5	139 ± 5	143 ± 5		151 ± 6
TdP+
HR	20	285 ± 7	280 ± 7	276 ± 6	258 ± 7	243 ± 7	233 ± 7	231 ± 7	237 ± 12	205 ± 23
QT	20	168 ± 4	166 ± 4	166 ± 4	172 ± 4	177 ± 5	184 ± 6	189 ± 6	187 ± 6	199 ± 15
TpTe	20		51 ± 3					60 ± 5		60 ± 5
TWLI	18		0.08 ± 0.01					0.12 ± 0.02	n.d.	n.d.
DAP	20	90 ± 3	93 ± 2	102 ± 3	106 ± 3	109 ± 3	112 ± 4	115 ± 2		111 ± 6
SAP	20	115 ± 3	117 ± 3	126 ± 3	131 ± 4	135 ± 3	139 ± 4	146 ± 4		140 ± 6

All values are means ± SEM. There was no significant difference in the respective values of any variable between the ‘TdP+’ and ‘TdP−’ groups of animals at any time point. For further details, see Table 1.

Phenylephrine, time points when phenylephrine is infused at increasing rates; Phe + Dof, time points when phenylephrine and dofetilide are infused simultaneously (see Figure 1 for protocol); n, number of animals in which the parameter was determined at 0 or 10 min (n declined due to arrhythmia occurrence at later time points); HR, sinus heart rate (min⁻¹); QT, the electrocardiographic QT interval (ms); TpTe, the electrocardiographic T_peak–T_end interval (ms); TWLI, T-wave lability index; DAP, diastolic arterial pressure (mmHg); SAP, systolic arterial pressure (mmHg); n.d. not determined.