Figure 3.

Effect of MEN16132, dexamethasone and dexketoprofen on the carrageenan-induced knee joint oedema (A) and neutrophil infiltration (B). Rats received drugs intra-articularly in the right knee at the doses indicated, 30 min before injection of saline (control group) or λ-carrageenan (2%, 25 µL) and the knee joint diameter and myeloperoxidase activity were measured 6 h later. Dotted lines indicate the control value (lower) and the response after carrageenan treatment (upper). Data are expressed as the mean ± SEM of 6–12 experiments. *P < 0.05 and °P < 0.05, significantly different from the carrageenan-treated group and control group respectively (one-way anova followed by Dunnett's post-test).