Figure 6.

Effect of dexamethasone on carrageenan-induced activation of the kinin-kallikrein system in the rat knee joint. Carrageenan (2%, 25 µL) or saline (control group) were injected intra-articularly into the right knee. After 6 h, a joint lavage was performed by saline perfusion, and synovial levels of either plasma kallikrein (A), tissue kallikrein (B) or bradykinin (C) were measured. Dexamethasone (100 µg per knee) was given 30 min before carrageenan administration. Data are expressed as the mean ± SEM of 8–12 experiments. *P < 0.05 significantly different from the saline-treated group (one-way anova followed by Dunnett's post-test). n.s., not significant.