Table 1.

Combination between kinin B₂ receptor antagonists (MEN16132 or icatibant) and anti-inflammatory steroids (dexamethasone or hydrocortisone) on carrageenan-induced inflammation

		oedema	MPO
treatment	µg per knee	% inhibition
MEN16132	100	46.3 ± 3.3*	67.5 ± 5.6*
icatibant	100	46.2 ± 6.3*	27.7 ± 19.3
dexamethasone	100	52.4 ± 2.5*	60.3 ± 4.8*
hydrocortisone	100	0.0 ± 3.3	0.0 ± 8.6
Icatibant + dexamethasone	100 + 100	90.4 ± 3.8*	71.9 ± 5.2*
MEN16132 + hydrocortisone	100 + 100	84.6 ± 6.3*	78.3 ± 0.6*

Data are expressed as the mean ± SEM of six experiments.

^*P < 0.05 significant inhibition of the carrageenan-treated group (one-way anova followed by Dunnett's post-test).