Table 2.

Interactions between MEN16132 and dexamethasone in inhibiting carrageenan-induced joint inflammation

drug combination
MEN16132	dexamethasone	pain	oedema combination index (CI)	MPO activity
µg per knee
10	10	0.129	0.097	0.116
30	30	0.007	0.119	0.154
100	10	0.005	0.031	0.214
100	3	0.001	0.040	0.217

Recommended descriptions of the degrees of synergism: CI < 0.1 very strong synergism, 0.1 < CI < 0.3 strong synergism, 0.3 < CI < 0.7 synergism, 0.7 < CI < 0.85 moderate synergism, 0.85 < CI < 0.9 slight synergism, 0.9 < CI < 1.1 nearly additive effect.