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Time-course effects on changes in mean arterial blood pressure (ΔMAP) and heart rate (ΔHR) induced by i.c.v. (A) or ventral tegmental area (VTA) (B) injection of 500 pmol of SB222200 or its inactive enantiomer SB222201. Areas under the curves (AUC) were measured for a period of 0–10 h for i.c.v and 0–8 h for VTA (small insets). Values represent the mean ± SEM of n rats. Significant difference from aCSF is indicated by *P < 0.05; **P < 0.01; ***P < 0.001.
