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Time-course effects on changes in mean arterial blood pressure (ΔMAP) and heart rate (ΔHR) induced by i.c.v. injection of 500 pmol R-820, once daily for a period of 5 days in spontaneously hypertensive rats. Values represent the mean ± SEM of four rats. Significant difference from pre-injection values is indicated by *P < 0.05; **P < 0.01.
