Figure 10.

Time-course effects on changes in mean arterial blood pressure (ΔMAP) produced by senktide injected i.c.v. on the (A) ipsilateral and (B) contralateral sides before and after SB222200 (500 pmol) injected into the ventral tegmental area (VTA). The anti-hypertensive effect elicited by the VTA injection of SB222200 (500 pmol) was measured before and after i.c.v. injection of senktide (65 pmol) on the ipsilateral (C) and contralateral (D) side in spontaneously hypertensive rats. Areas under the curves (AUC) for MAP are shown in (E and F). Values represent the mean ± SEM of n rats. Significant difference from aCSF (*) and senktide alone or SB222200 alone (†) is indicated by *†P < 0.05; **††P < 0.01; ***†††P < 0.001.