Analysis of mammary tumors in PISA mice (N=10), with or without Ponasterone A-induced IκBαSR expression to determine: A, Microvessel density; B, Histopathology by hematoxylin and eosin staining (left), immunostaining to demarcate CD31 (middle), CD34 (right) positive tumor blood vessels and C, immunohistochemical staining for candidate proangiogenic factors; E, Quantitation of immunohistochemical staining for proangiogenic factors, shown as mean + SEM (* P< 0.05, ** P<0.01). All pictures taken using 40x objective.